Adolescent vulnerability to methamphetamine: Dose-related escalation of self-administration and cue extinction deficits

Abstract

Adolescence is the most vulnerable period for developing substance use disorders, with adolescents relapsing more compared to adults even after therapy. Methamphetamine is a widely-used illicit psychostimulant by adolescents that is showing a world-wide increase in its purity. However, how adolescents respond to changing doses of methamphetamine or reinstate use after therapy is poorly understood. Therefore, we examined intravenous self-administration of methamphetamine at varying doses followed by instrumental extinction, cue extinction and cue-induced reinstatement of methamphetamine seeking in adolescent and adult rats. We observed with two different starting doses (0.03 or 0.1 mg/kg/infu..